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Black cohosh and St. John’s Wort

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By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Menopausal symptoms

Source: Obstetrics & Gynecology, February, 2006;107:247-255.

Research: The objective of the study was to investigate the efficacy of a fixed combination of black cohosh (Cimicifuga racemosa) and St. John’s Wort (Hypericum perforatum) extracts in women with climacteric complaints with a pronounced psychological component. In the double-blind, randomized, placebo-controlled study, 301 women experiencing meno-pausal complaints with psychological symptoms were treated with ethanolic St. John’s Wort extract and isopropanolic black cohosh extract or a matched placebo for 16 weeks. Menopausal complaints were evaluated by means of the Meno-pause Rating Scale mean score, and psychological complaints were evaluated using the Hamilton Depression Rating Scale sum score.

Results: Results proved that the mean Menopause Rating Scale score decreased 50% in the treatment group and 19.6% in the placebo group. The Hamilton Depression Rating Scale total score decreased 42% in the treatment group and 12.7% in the placebo group. According to researchers, the treatment was significantly superior to placebo in both measures. There were no relevant group differences regarding adverse events, laboratory values or tolerability. It was therefore concluded that this fixed combination of black cohosh and St. John’s Wort is superior to placebo in alleviating menopausal complaints, including the related psychological component.

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